Most chemists use structures extensively in their daily work. There are excellent graphical tools on the market which are now the de-facto standard for drawing and manipulating structures. Ideally, chemists would use the same graphic tools in chemistry databases to search for structures. The integration of the graphical structure searching tools in chemistry databases has been greatly improved over the past several years. Reaxys currently incorporates two major structure drawing tools: Marvin JS and ChemDraw JS. These tools are integral part of the database query design process and are accessible from multiple entry points in Reaxys. How does Reaxys interpret structures drawn by the graphics tools? Are there any features and hidden obstacles chemists should be aware when designing queries with the help of graphical tools? We will discuss some of these issues in the session. We also discuss pros and cons of structure searching using Marvin or ChemDraw graphical tools.